Antibody Offers New Hope Against Ovarian Cancer

Ovarian cancer has been fatal for women. More and more women are becoming victims of this cancer. More than 21,000 cases of this disease have been recorded during the year 2009. Statistics reveal that women who have been diagnosed with this cancer when they were less than 30 years have more chances of survival than older women who have crossed 50.

In ovarian cancer, the lethal cancer cells get accumulated in the ovaries. Since ovaries are important for producing eggs for reproduction, this deadly disease affects the female reproductive and sexual organs. Different types of tumor cells like stromal, germ cell and epithelial tumors cause this type of cancer.

A lot of research has gone into fighting the numerous cancer cells that affect the individuals. With all treatments and medications, scientists find it a challenge to treat this disease.

Lately, a new antibody has been found by the researchers in order to fight against the cancer cells that attack the immune system of the body. This has offered new hopes for treating ovarian cancer among women.

This antibody named AD5-10 attaches to the cancer cells weakening the resistance of the tumor cells to the body’s immune system. In addition, this antibody is found to be more effective for chemotherapy.

AD5-10 antibody decreases resistance of the cells to carboplatin, a common agent used in chemotherapy. The combined effect of this antibody along with carboplatin was more effective for treating cancer patients. Reports also revealed that the antibody is found to react in this manner only when the cell killers known as lymphocytes NK are present in the tumor cells during the same time.

Overcome Infertility – Anti-Nuclear Antibody (ANA) In Conventional Perspective

As we mentioned in previous article, conventional medicine plays an important role in treating all kinds of disease and most of the time is the first treatment for a couple who for what ever reason cam not conceive after 1 year of unprotected sexual intercourse or can not carry the pregnancy to full term. Immune system plays an important role in protect our body against forming of free radicals and bacteria and virus, but for what ever reasons, sometime the immune system attack sperm in the women reproductive organs or sperm in the testes in men, leading to infertility In this article, we will discuss how anti-nuclear antibody (ANA) affects fertility in conventional perspective.

1. Definition
Antinuclear antibody is defined as specific class of auto antibodies that have the ability to attack structures in the nucleus of cells instead of performing the normal antibody function. It can be detected through blood sample withdrawn from the patient’s vein.

2. Causes
a) Infection and inflammation
Infection and inflammation caused by bacteria or virus speeding up the body immune system function, but in some cases, bacteria and virus induce the immune system to produce antibodies which directed against the tissues of the body.
b) Medication

i) Phenytoin
Pheytoin may increase the risk of production of antinuclear antibody, leading to increasing the risk of malformations and birth defects.
ii) Antibotics
Long term uses of antibody may increase the rick of the production of antinuclear antibody as the medication causes abnormal reaction to the immune system.
iii) Methyldopa
The medication is used to dilate blood vessels for treating high blood pressure, but long term use of this type of medication may decrease the risk of immune disorder in production of antinuclear antibody.

c) Aging
As we age, the levels of antinuclear antibody increases and in some older adults (5% to 40%) may have mildly elevated levels caused by weakening immune function.
d) Diseases
Some diseases such as lupus erythematosus and rheumatoid arthritis may also increase the rick of the production of antinuclear antibody.

3. How antinuclear antibody effects infertility
Under normal conditions, when a woman becomes pregnant, the white blood cells in her uterus produce protective, blocking antibodies. In case of antinuclear antibody, the white blood cells recognize the fetus as a foreign invasion and attack it, leading to miscarriage.

4. Treatment
a) Heparin
Heparin is a member of anticoagulants,it is a purified preparation derived from animal tissue. It helps to increase the blood in transportation of nutrients to the reproductive organs leading to high chance of fertility and lessening the risk of pregnancy loss.
b) Aspirin
Aspirin is an anti-inflammatory and blood thinner agent, it helps to increase the blood circulating to the reproductive organs, thereby reducing the risk of antinuclear antibody attacking the fetus or the women reproductive tissues. It is recommendation to take 80 mg per day, which is equivalent to a baby aspirin. if necessary.

Monoclonal Antibodies – For The Treatment Of Various Diseases

Monoclonal antibodies are widely used for the treatment of various types of cancers. They are mainly involved in immunotherapy. Clinical study is conducting on various monoclonal antibodies and other related proteins. Many of these antibodies are being approved for diseases like inflammation and cancer. A lot of researches are conducting to create monoclonal antibodies that are able to cure various diseases.

Some of the diseases cured by these antibodies include:

• Various types of cancers
• Rheumatoid arthritis
• Tumors
• Multiple sclerosis
• Lymphoma

What Is Antibody Screening and Phage Display?

Antibody screening is the process used for identifying productive cell lines. This will help to minimize the cost of downstream processing steps. Early identification of productive cell lines will enhance the success in scale up activities. Phage display screening process is mainly used for the identifying high affinity antibodies or peptides. Following are some of the important uses of phage display:

• Used for screening protein interaction
• Help to analyze the mechanism or functioning of a protein
• One of the important techniques used in protein engineering.
• Considered as a tool in medicine or drug discovery
• Help to determine tumor antigens

Function of Antibodies

The immune system of our body is capable of generating certain antibodies. These antibodies will attach foreign substances called antigens and neutralize or destroy them. If our body is exposed to a bacteria or virus, then it will get rid of infection by producing antibodies. Antibodies are considered as the natural defensive substances. They are generally produced by the B cell of the immune system. They help in the recognition of foreign antibodies and then stimulate immune response to them. Antigen presenting cells are involved in adaptive immune response.

Important Medications Using Monoclonal Antibodies

Monoclonal antibodies can be used in different forms of therapy. They are used for blocking certain cell receptors and also for destroying malignant tumor cells. There are also variations within the treatment procedures. These types of treatment mainly include medications like Bexxar, Herceptin and Rituxan. Bexxar contains a radioactive iodine molecule and so it does not have a naked form. This medicine has some negative effects like fever, shakes or chills. Medication involving Herceptin is specific for destroying cancer cells in the breast. Treatment procedure that involves Rituxan is very much effective in treating various types of lymphomas, especially Non-Hodgkin’s lymphoma.

Various Aspects of Monoclonal Antibody Therapy

Monoclonal antibody therapy is quite effective and safe for certain patients. This treatment is not suitable for routine clinical setting because it have to be tailored to each individual patient. This technology is effective in creating antibodies against certain antigens present on the tumor surfaces. These are laboratory produced substances which are able to produce anti-tumor effects. They have been used with radioactive particles or toxins for killing cells. They are mainly used for binding molecule called tumor necrosis factor (TNF). TNF is the main cause of inflammation and rheumatoid arthritis. Monoclonal proteins called Remicade and Humira are TNF inhibitors.

Medical Researchers Need the Best From Antibody Manufacturers

I’ve had a long-standing interest in genetic engineering and longevity related research. In fact since the age of 11 years old, I have always thought that dying is a stupid way to live, and it has always annoyed me the most people think that old age is a normal part of life rather than the disease that it is. Aging in many ways is about our bodies rusting just like iron rusts when exposed to oxygen, the human bodies also is damaged at the genetic level by free radical oxygen molecules. And there are other causes for aging related to the way proteins act in our system, the way junk builds up in our cells, other junk builds up between our cells and how our DNA repair-kit gets damaged through the metabolism of living.

Then there is the issue of antibodies which are also known as immunoglobulins which are gamma globulin proteins found in our bloodstream or other fluids in the body of all vertebrates including people. They are used by our immune system to identify, target and to neutralize or destroy the many foreign objects present at any moment in time including bacteria and viruses.

Aging is a disease, and there is nothing natural or romantic about it. It brings on a long and torturous death by a multitude of painful and serious medical problems and a tremendous loss of quality of life along the way. The nonsense of the Bush government blocking genetic research is thankfully passed, and so America may even begin to catch up a little on the progress made by the rest of the world – though many great minds from the American research community have already migrated to Europe.

Thankfully modern research is now focused on getting to the root cause of each and every known issue that impacts on our health. In my resource box is a link to one antibody manufacturer that already has 11,000 antibodies that it routinely produces for its research clients worldwide as they investigate diseases and formulate drugs and medical treatments and this company releases an extra 200 antibody products a month to keep pace with the needs of researchers. Indeed they claim to have 17,000 additional antibodies in their development pipeline to assist in the global research for the highest quality of life for the rest of us.